GuideRails Holistic - Support System We’ve shifted our focus beyond the feet, to the most injury-prone part of a runner’s body: the knees. GuideRails keep you moving comfortably by keeping excess movement in check. Super-Soft Cushioning - The DNA LOFT cushioning provides a soft, luxurious feeling underfoot without losing responsiveness or durability, while the OrthoLite® sockliner provides premium step-in comfort. Plush FIt - The plush feel of an internal stretch bootie surrounds your foot and moves and expands with your stride. The engineered mesh upper and 3D Fit Print technology only enhance the fit.